Article

ALS-associated RNA binding proteins converge on <i>UNC13A</i> transcription through regulation of REST

2024-10-23

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective loss of motor neurons. Although multiple pathophysiological mechanisms have been identified, a unified molecular basis for ALS has remained elusive. The ALS-associated RNA binding protein (RBP) TDP-43 has previously been shown to stabilize UNC13A mRNA by preventing cryptic exon inclusion. We here show that three ALS-...

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Literature Corpus work: 9ff768fa-26d9-5e06-a8f0-ee352c5ce9dc
DOI: 10.1101/2024.10.22.619761

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