Article

Prostacyclin synthase deficiency exacerbates inflammatory reactions in lipopolysaccharide-induced sepsis in vivo

2024-02-28

Abstract excerpt

<title>Abstract</title> <p>Objectives Sepsis is an inflammatory disorder characterized by life-threatening organ dysfunction resulting from a dysregulated host response to infection. In contrast, prostacyclin (PGI<sub>2</sub>) is a bioactive lipid produced by PGI synthase (PGIS) and is known to play important roles in inflammatory reactions as well as cardiovascular regulation. However, little is known about the...

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Literature Corpus work: 9f994d81-5636-5241-8d57-58c6219f476f
DOI: 10.21203/rs.3.rs-3972516/v1

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