Article

Inhibition of LOX-1 ameliorates coagulation and inflammation in sepsis by suppressing the JAK2/STAT3 pathway

2024-11-28

Abstract excerpt

<title>Abstract</title> <p>Lectin-like oxidised low-density lipoprotein receptor-1 (LOX-1) is a transmembrane protein that belongs to the C-type lectin family and plays a significant role in various diseases by promoting the release of inflammatory mediators and enhancing cellular responses to oxidative stress. Studies have demonstrated that in sepsis, activation of LOX-1 promotes a procoagulant phenotype in endo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5cd73ef3-dfd4-5327-85f6-b9a65b80b371
DOI: 10.21203/rs.3.rs-5417565/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of LOX-1 ameliorates coagulation and inflammation in sepsis by suppressing the JAK2/STAT3 pathwayDOI 10.21203/rs.3.rs-5417565/v1Read

Unraveling the Intricate Web: Complement Activation Shapes the Pathogenesis of Sepsis-Induced CoagulopathySemantic proximity Read

The dysfunction of complement and coagulation in diseases: the implications for the therapeutic interventionsSemantic proximity Read

Molecular basis of endothelial dysfunction in sepsis.Semantic proximity Read

Exploring the Mechanism of Coagulation Dysfunction in a Sepsis Model though Gene Expression ProfilesSemantic proximity Read

Interactions between Coagulation and InflammationSemantic proximity Read

Targeting STAT3: A crucial modulator of sepsisSemantic proximity Read

HS3ST1 regulates pulmonary inflammation and is a determinant of clinical outcomes after trauma and hemorrhagic shockSemantic proximity Read

The Angiopoietin-Tie2 Signaling Axis in Systemic InflammationSemantic proximity Read

Role of the complement in experimental sepsisSemantic proximity Read

Caspase-Driven Microvascular Inflammation and Hypoperfusion in Intravascular Hemolysis: Roles of Leukocyte and Endothelial ActivationSemantic proximity Read

Sepsis decreases lung SVEP1 expression in a murine modelSemantic proximity Read

PECAM-1 protects against DIC by dampening inflammatory responses via inhibiting macrophage pyroptosis and restoring vascular barrier integrity.Semantic proximity Read