Article

Influences of rare protein-coding genetic variants on the human plasma proteome in 50,829 UK Biobank participants

2022-10-11

Abstract excerpt

Combining human genomics with proteomics is becoming a powerful tool for drug discovery. Associations between genetic variants and protein levels can uncover disease mechanisms, clinical biomarkers, and candidate drug targets. To date, most population-level proteogenomic studies have focused on common alleles through genome-wide association studies (GWAS). Here, we studied the contribution of rare protein-coding v...

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Literature Corpus work: 082ef8e6-9a81-5f9f-8c74-6e49795ee3fc
DOI: 10.1101/2022.10.09.511476

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