Article

Targeting MYC Overexpressing Leukemia with Cardiac Glycoside Proscillaridin Through Downregulation of Histone Acetyltransferases

2018-10-15

Abstract excerpt

<h4>ABSTRACT</h4> Targeting MYC oncogene remains a major therapeutic goal in cancer chemotherapy. Here, we demonstrate that proscillaridin, a cardiac glycoside approved for heart failure treatment exhibit anticancer selectivity towards high MYC expressing leukemic cell lines and leukemia stem cells. At a clinically relevant concentration, proscillaridin induced a rapid downregulation of MYC protein level, due to...

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Literature Corpus work: 9f46bbf6-7886-5ad2-b39c-bd32f98569d9
DOI: 10.1101/444133

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