Article

Early life adversity promotes gastrointestinal dysfunction through a sex-dependent phenotypic switch in enteric glia

2024-06-03

Abstract excerpt

Irritable bowel syndrome and related disorders of gut-brain interaction (DGBI) are common and exhibit a complex, poorly understood etiology that manifests as abnormal gut motility and pain. Risk factors such as biological sex, stressors during critical periods, and inflammation are thought to influence DGBI vulnerability by reprogramming gut-brain circuits, but the specific cells affected are unclear. Here, we use...

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Literature Corpus work: 9f31557f-d6a2-5c54-85a4-522da3b812d5
DOI: 10.1101/2024.05.31.596805

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