Article

Dysfunction of proprioceptive sensory synapses is a pathogenic event and therapeutic target in mice and humans with spinal muscular atrophy

2024-06-04

Abstract excerpt

<h4>ABSTRACT</h4> Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by a varying degree of severity that correlates with the reduction of SMN protein levels. Motor neuron degeneration and skeletal muscle atrophy are hallmarks of SMA, but it is unknown whether other mechanisms contribute to the spectrum of clinical phenotypes. Here, through a combination of physiological and morphological s...

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Literature Corpus work: 9ed0efc1-1da1-5626-9c15-38cab11facb1
DOI: 10.1101/2024.06.03.24308132

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