Article

Mitigating the Stage-Cliff: Continuous Spatial Validation of the Ghartey Scalar Model in the METABRIC Cohort

2026-05-11

Abstract excerpt

<h4>Background: </h4> Categorical TNM staging evaluates anatomical mass in a vacuum, creating artificial prognostic "cliffs" and ignoring cellular kinetics. The Ghartey et al Frugal Scalar Model introduced a kinetic paradigm to oncology—1 / ([Mass] x [Velocity]) —demonstrating that multiplying mass by proliferative velocity significantly improves prognostication. However, its initial iterations remained mathematic...

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Literature Corpus work: 9e2d8012-80eb-54c0-a17c-f489e935af8e
DOI: 10.20944/preprints202605.0659.v1

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