Article

Latent Epigenetic Programs in Müller Glia Contribute to Stress, Injury, and Disease Response in the Retina

2023-10-17

Abstract excerpt

<h4>ABSTRACT</h4> Previous studies have demonstrated the dynamic changes in chromatin structure during retinal development that correlate with changes in gene expression. However, a major limitation of those prior studies was the lack of cellular resolution. Here, we integrate single-cell (sc) RNA-seq and scATAC-seq with bulk retinal data sets to identify cell type–specific changes in the chromatin structure duri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9d9d884b-fc59-5373-aa0f-0c3331d1609c
DOI: 10.1101/2023.10.15.562396

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Latent Epigenetic Programs in Müller Glia Contribute to Stress, Injury, and Disease Response in the RetinaDOI 10.1101/2023.10.15.562396Read

Cross-species transcriptomic and epigenomic analysis reveals key regulators of injury response and neuronal regeneration in vertebrate retinasSemantic proximity Read

The transcriptome of retinal Müller glial cellsSemantic proximity Read

Integrative Single‐Cell Transcriptomics and Epigenomics Mapping of the Fetal Retina Developmental DynamicsSemantic proximity Read

Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regenerationSemantic proximity Read

Single-cell RNA-seq analysis maps the development of human fetal retinaSemantic proximity Read

Translatomic response of retinal Müller glia to acute and chronic stressSemantic proximity Read

AI-Driven Analysis Unveils Functional Dynamics of Müller Cells in Retinal Autoimmune InflammationSemantic proximity Read

Sacrificing Adaptability for Functionality: The Ivory Tower of Macular Müller CellsSemantic proximity Read

Generation of human neural retina transcriptome atlas by single cell RNA sequencingSemantic proximity Read

Genetic and epigenetic regulators of retinal Müller glial cell reprogrammingSemantic proximity Read

Cis-Regulatory Accessibility Directs Muller Glial Development and Regenerative CapacitySemantic proximity Read

Comparative single-cell multiomic analysis reveals evolutionarily conserved and species-specific cellular mechanisms mediating natural retinal agingSemantic proximity Read