Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19.

doi:10.1172/jci.insight.150862

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Article

Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19.

JCI insight - 22 Sept 2021

Kaiser Rainer, Leunig Alexander, Pekayvaz Kami, Popp Oliver, Joppich Markus, Polewka Vivien, Escaig Raphael, Anjum Afra, Hoffknecht Marie-Louise, Gold Christoph, Brambs Sophia, Engel Anouk, Stockhausen Sven, Knottenberg Viktoria, Titova Anna, Haji Mohamed, Scherer Clemens, Muenchhoff Maximilian, Hellmuth Johannes C, Saar Kathrin, Schubert Benjamin, Hilgendorff Anne, Schulz Christian, Kääb Stefan, Zimmer Ralf, Hübner Norbert, Massberg Steffen, Mertins Philipp, Nicolai Leo, Stark Konstantin

Abstract excerpt

Neutrophils provide a critical line of defense in immune responses to various pathogens, inflicting self-damage upon transition to a hyperactivated, procoagulant state. Recent work has highlighted proinflammatory neutrophil phenotypes contributing to lung injury and acute respiratory distress syndrome (ARDS) in patients with coronavirus disease 2019 (COVID-19). Here, we use state-of-the art mass...

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PMID: 34403366
DOI: 10.1172/jci.insight.150862
PMCID: PMC8492337

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