Article

A novel hypothesis-generating approach for detecting phenotypic associations using epigenetic data

2024-01-16

Abstract excerpt

<h4>A bstract </h4> <h4>Background</h4> Hypotheses about what phenotypes to include in causal analyses (that in turn can have clinical and policy implications) can be guided by hypothesis-free approaches, leveraging the epigenome for example. Materials & methods: Minimally adjusted epigenome-wide association studies (EWAS) using ALSPAC data were performed for example conditions, dysmenorrhea and heavy menstrual bl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9cc19225-b1f6-5f0d-a4f8-91f580662b7c
DOI: 10.1101/2024.01.15.24301219

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A novel hypothesis-generating approach for detecting phenotypic associations using epigenetic dataDOI 10.1101/2024.01.15.24301219Read

A novel hypothesis-generating approach for detecting phenotypic associations using epigenetic data.Semantic proximity Read

EpipwR: Efficient Power Analysis for EWAS with Continuous OutcomesSemantic proximity Read

Social Determinants of Health and Lifestyle Risk Factors Modulate Genetic Susceptibility for Women's Health Outcomes.Semantic proximity Read

Decoding the regulatory genetic architecture of endometriosis using AlphaGenomeSemantic proximity Read

Genetic prediction of long-term effects of aromatase inhibition on cancer and non-neoplastic disease riskSemantic proximity Read

Genome-Wide Association Study of Distressing Premenstrual Symptoms in Two Nordic PopulationsSemantic proximity Read

Whole-genome methylation profiling of menstrual stem cells identifies novel biomarkers for endometriosisSemantic proximity Read

Genetic risk stratification and risk factors of early menopause in women: a multi-center study utilizing polygenic risk scores.Semantic proximity Read

Methylation Risk Score Modelling in Endometriosis: Evidence for Non-Genetic DNA Methylation Effects in a Case–Control StudySemantic proximity Read

Hidden hypotheses in 'hypothesis-free' genome-wide epigenetic associations.Semantic proximity Read

Former smoking associated with epigenetic modifications in human granulosa cells among women undergoing assisted reproductionSemantic proximity Read

Circulating anti-Müllerian hormone levels in pre-menopausal women: novel genetic insights from a GWAS meta-analysisSemantic proximity Read