Article

Repurposing proteasome inhibitors in the treatment of esophageal squamous cell cancer

2026-03-13

Abstract excerpt

<title>Abstract</title> <p> <bold>Background.</bold> Esophageal squamous cell cancer (ESCC) is characterized by poor prognosis and limited options due to the lack of general effective chemotherapy method. Immune and targeted therapy have made progress in recent years, but only a few patients can benefit from them. <bold>Methods.</bold> In this study, a high-throughput in vitro drug sensitivity screening was c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1705972a-531c-5014-845a-ff6c2b530f3e
DOI: 10.21203/rs.3.rs-8958728/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Repurposing proteasome inhibitors in the treatment of esophageal squamous cell cancerDOI 10.21203/rs.3.rs-8958728/v1Read

Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinomaSemantic proximity Read

Romidepsin exhibits anti-esophageal squamous cell carcinoma activity through the DDIT4-mTORC1 pathwaySemantic proximity Read

The Second-Generation Proteasome Inhibitor Ixazomib Enhances the Anticancer Effects of Gemcitabine or Fluorouracil in Pancreatic Cancer CellsSemantic proximity Read

CDK4/6 Inhibition Uncovers Subtype-Specific Vulnerabilities and Immune-Related Responses in Esophageal Squamous Cell CarcinomaSemantic proximity Read

Identification of 2 Ubiquitin-Proteasome System-Related Subtypes in Esophageal Squamous Cell Carcinoma for Prognostic and Immunotherapeutic Response Prediction.Semantic proximity Read

Leveraging single-cell and multi-omics approaches to identify MTOR-centered deubiquitination signatures in esophageal cancer therapy.Semantic proximity Read

Potential Role of Targeting KDR and Proteasome Inhibitors in the Therapy of Esophageal Squamous Cell Carcinoma.Semantic proximity Read

Actionable Alterations for Molecular Targeted Therapy in Esophageal Cancer: An AACR Project GENIE ReviewSemantic proximity Read

Correlation Between Drug Sensitivity Profiles of Ex Vivo Expanded Circulating Tumor Cells and Clinical Treatment Response in Pancreatic Ductal Adenocarcinoma PatientsSemantic proximity Read

Cell line modeling for systems medicine in cancers (Review)Semantic proximity Read

Anlotinib inhibits the development of esophageal squamous cell carcinoma by regulating the PI3K/AKT signaling pathwaySemantic proximity Read

Daurisoline Suppresses Growth of Esophageal Squamous Cell Carcinoma by Inhibiting MEK1/2 In Vitro and In VivoSemantic proximity Read