Article

Colorectal cancer risk variants in the 11q13.4 locus are associated with variable POLD3 transcript expression which may promote DNA damage and telomere shortening in colorectal cancer cells

2025-12-27

Abstract excerpt

DNA Polymerase Delta (Pol δ) acts in DNA synthesis and in DNA repair, both important factors in the proliferative nature, longevity, and mutability of cancer cells. The chromosomal region containing POLD3 , the third subunit of Pol δ, has recently been identified by genome wide-association studies as containing single nucleotide polymorphisms (SNPs) that increase the risk of colorectal cancer (CRC). Here, we hav...

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Literature Corpus work: 9c5ffdbd-d334-5168-a877-b21e7445be88
DOI: 10.64898/2025.12.19.25342655

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