Article

Fatty Acid Synthase associates with nuclear-derived cytoplasmic dsRNA molecules and influences antiviral innate immune response

2025-07-18

Abstract excerpt

Cytoplasmic double-stranded RNA (dsRNA) is a hallmark of viral infection. It triggers innate immune responses after recognition by pathogen recognition receptors (PRRs) and leads to the production of interferons. DsRNAs arising from endogenous transcripts can also contribute to immune regulation, depending on their abundance, localization and processing. However, the mechanisms of their immunogenic potential and i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c3b07de-6900-578a-b84c-d47f40524e88
DOI: 10.1101/2025.07.16.662511

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fatty Acid Synthase associates with nuclear-derived cytoplasmic dsRNA molecules and influences antiviral innate immune responseDOI 10.1101/2025.07.16.662511Read

Integrative transcriptomic and genomic analyses unveil the IFI16 variants and expression as MASLD progression markersSemantic proximity Read

Unveiling the role of disulfidptosis-related genes in the pathogenesis of non-alcoholic fatty liver diseaseSemantic proximity Read

A conventional immune regulator mitochondrial antiviral signaling protein blocks hepatic steatosis by maintaining mitochondrial homeostasisSemantic proximity Read

Suppressing fatty acid synthase by type I interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2Semantic proximity Read

Prominent Increases of Nuclear DNAJA3and Cytosolic STAT1 with Nucleic Acid Sensors Underlie Innate Immunity Activation in ClpP-null MouseSemantic proximity Read

Deoxyguanosine Kinase Deficiency Couples Purine Metabolism to Innate Immune Activation and Lipid Accumulation in HepatocytesSemantic proximity Read

ssRNA Virus and Host Lipid Rearrangements: Is There a Role for Lipid Droplets in SARS-CoV-2 Infection?Semantic proximity Read

Elevated levels of intracellular RNA lariats suppress the antiviral responseSemantic proximity Read

ISG15, a Small Molecule with Huge Implications: Regulation of Mitochondrial HomeostasisSemantic proximity Read

Distinct interactomes of ADAR1 nuclear and cytoplasmic protein isoforms and their responses to interferon inductionSemantic proximity Read

Host A-to-I RNA editing signatures in intracellular bacterial and single-strand RNA viral infectionsSemantic proximity Read

SLIRP promotes autoimmune diseases by amplifying antiviral signaling via positive feedback regulationSemantic proximity Read