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Article

Identification of genes associated with resilience/vulnerability to sleep deprivation and starvation in Drosophila.

Sleep - 1 May 2015

Thimgan Matthew S, Seugnet Laurent, Turk John, Shaw Paul J

Abstract excerpt

BACKGROUND AND STUDY OBJECTIVES: Flies mutant for the canonical clock protein cycle (cyc(01)) exhibit a sleep rebound that is ∼10 times larger than wild-type flies and die after only 10 h of sleep deprivation. Surprisingly, when starved, cyc(01) mutants can remain awake for 28 h without demonstrating negative outcomes. Thus, we hypothesized that identifying transcripts that are differentially regulated between...

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Identifiers

PMID: 25409104
DOI: 10.5665/sleep.4680
PMCID: PMC4402663

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