Electronic health records to test multimorbidity influences to plasma biomarker interpretation for Alzheimer’s disease

Abstract excerpt

<h4>Objective</h4> Plasma biomarkers of Alzheimer’s disease (AD) pathology are frequently tested in specialized research settings, limiting generalizability of findings. Using electronic health records and banked plasma, we evaluated plasma biomarkers – phosphorylated tau 217 (p-tau 217 ), β-amyloid 1-42/1-40 (Aβ 42 /Aβ 40 ) and p-tau 217 /Aβ 42 – in a real-world, diverse clinical population with multimorbidities...

Topics

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• Alzheimer Disease
• Amyloid beta-Peptides
• Chronic Disease
• Cognition
• Cognitive Dysfunction
• Dementia, Vascular
• Disease Progression
• tau Proteins

Identifiers and source

Literature Corpus work

9af87ab7-da59-505e-b926-e0e02fb47247

DOI

10.1101/2025.08.16.25333799