Article

Activation of the alternative complement pathway and its relevance for sodium retention in experimental nephrotic syndrome

2025-08-29

Abstract excerpt

<title>Abstract</title> <p> The complement component C3, factor B (FB) and factor D (FD) belong to the alternative complement pathway and have been identified in urine samples from nephrotic mice. However, it is not yet known whether these factors are involved in mediating sodium retention in nephrotic syndrome (NS). Here we used a genetic mouse model of NS based on an inducible podocin deletion ( <italic>Nphs2...

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Literature Corpus work: 9ae3d81d-c5e6-5902-aa21-73a6cb57a6a2
DOI: 10.21203/rs.3.rs-7419134/v1

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