Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A 5' UTR Mutation Contributes to Down-Regulation of Bbs7 in the Berlin Fat Mouse.

International journal of molecular sciences - 27 Oct 2022

Mohebian Kourosh, Hesse Deike, Arends Danny, Brockmann Gudrun A

Abstract excerpt

The Bardet-Biedl Syndrome 7 (Bbs7) gene was identified as the most likely candidate gene causing juvenile obesity in the Berlin Fat Mouse Inbred (BFMI) line. Bbs7 expression is significantly lower in the brain, adipose tissue, and liver of BFMI mice compared to lean C57BL/6NCrl (B6N) mice. A DNA sequence comparison between BFMI and B6N revealed 16 sequence variants in the Bbs7 promoter region. Here, we tested if...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bardet-Biedl Syndrome

Share to Cytoskeletal Proteins

Share to Down-Regulation

Share to Mice, Inbred C57BL

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 36361806
DOI: 10.3390/ijms232113018
PMCID: PMC9658298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A 5' UTR Mutation Contributes to Down-Regulation of Bbs7 in the Berlin Fat Mouse.PMID 36361806Read ↗

A 5’ UTR Mutation Contributes To Down-Regulation Of Bbs7 In The Berlin Fat MouseSemantic proximity Read ↗

Four out of eight genes in a mouse chromosome 7 congenic donor region are candidate obesity genes.Semantic proximity Read ↗

BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes.Semantic proximity Read ↗

Identification of compound heterozygous mutations in the BBS7 gene in a Korean family with Bardet-Biedl syndrome.Semantic proximity Read ↗

Molecular mechanisms of the obesity associated with Bardet-Biedl syndrome: An update.Semantic proximity Read ↗

Phenotypic characterization of Bbs4 null mice reveals age-dependent penetrance and variable expressivity.Semantic proximity Read ↗

The study of a total and two hypothalamic-specific BBS10 knockout models highlights the importance of systemic inactivation in the obese phenotype in Bardet Biedl SyndromeSemantic proximity Read ↗

BRD7 deficiency leads to the development of obesity and hyperglycemia.Semantic proximity Read ↗

A knockin mouse model of the Bardet-Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity.Semantic proximity Read ↗

Comparative genomics and gene expression analysis identifies BBS9, a new Bardet-Biedl syndrome gene.Semantic proximity Read ↗

A novel mutation in BBS7 gene causes Bardet-Biedl syndrome in a Chinese family.Semantic proximity Read ↗

Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.