Article

Role of matrix metalloproteinase-9 in neurodevelopmental disorders and experience-dependent plasticity in Xenopus tadpoles

2020-05-31

Abstract excerpt

Matrix metalloproteinase-9 (MMP-9) is a secreted endopeptidase targeting extracellular matrix proteins, creating permissive environments for neuronal development and plasticity. Developmental dysregulation of MMP-9 is also associated with neurodevelopmental disorders (ND). Here we test the hypothesis that chronically elevated MMP-9 activity during early neurodevelopment is responsible for neural circuit hyperconne...

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Literature Corpus work: 9a2be8db-e0b8-5f14-b7f1-f8bc22f4a2a9
DOI: 10.1101/2020.05.29.123661

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