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Article

Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Jul 2014

Sidhu Harpreet, Dansie Lorraine E, Hickmott Peter W, Ethell Douglas W, Ethell Iryna M

Abstract excerpt

Fmr1 knock-out (ko) mice display key features of fragile X syndrome (FXS), including delayed dendritic spine maturation and FXS-associated behaviors, such as poor socialization, obsessive-compulsive behavior, and hyperactivity. Here we provide conclusive evidence that matrix metalloproteinase-9 (MMP-9) is necessary to the development of FXS-associated defects in Fmr1 ko mice. Genetic disruption of Mmp-9 rescued...

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Identifiers

PMID: 25057190
DOI: 10.1523/JNEUROSCI.1162-14.2014
PMCID: PMC4107404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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