Article

Nerve pathology is prevented by linker proteins in mouse models for <i>LAMA2</i> -related muscular dystrophy

2022-05-20

Abstract excerpt

<h4>ABSTRACT</h4> LAMA2 -related muscular dystrophy (LAMA2 MD or MDC1A) is caused by mutations in the LAMA2 gene encoding laminin-α2, the long chain of several heterotrimeric laminins. Laminins are essential components of the extracellular matrix that interface with underlying cells. The pathology of LAMA2 MD patients is dominated by the severe muscular dystrophy but also involves other tissues. In the dy W /...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9a149862-1e03-5ac9-8078-042a41bec9fa
DOI: 10.1101/2022.05.19.492629

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nerve pathology is prevented by linker proteins in mouse models for <i>LAMA2</i> -related muscular dystrophyDOI 10.1101/2022.05.19.492629Read

Nerve pathology is prevented by linker proteins in mouse models for LAMA2 -related muscular dystrophySemantic proximity Read

Amelioration of muscle and nerve pathology of Lama2-related dystrophy by AAV9-laminin-αLN linker proteinSemantic proximity Read

Dual AAV gene therapy using laminin-linking proteins ameliorates muscle and nerve defects in LAMA2-related muscular dystrophySemantic proximity Read

Deregulation of multiple mechanisms shapes the onset of <i>LAMA2</i> -congenital muscular dystrophySemantic proximity Read

Laminin-deficient muscular dystrophy: Molecular pathogenesis and structural repair strategies.Semantic proximity Read

A Family of Laminin α2 Chain-Deficient Mouse Mutants: Advancing the Research on LAMA2-CMDSemantic proximity Read

Linker molecules between laminins and dystroglycan ameliorate laminin-α2–deficient muscular dystrophy at all disease stagesSemantic proximity Read

Matrix remodeling plays an etiological role in driving laminin-α2 deficient pathologySemantic proximity Read

LAMA2 Neuropathies: Human Findings and Pathomechanisms From Mouse ModelsSemantic proximity Read

A single point mutation in the LN domain of LAMA2 causes muscular dystrophy and peripheral amyelination.Semantic proximity Read

Human Laminin-111 and Laminin-211 protein therapy prevents muscle disease progression in an immune deficient mouse model of LAMA2-CMDSemantic proximity Read

Distinct Roles for Laminin Globular Domains in Laminin α1 Chain Mediated Rescue of Murine Laminin α2 Chain DeficiencySemantic proximity Read