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Article

Transcriptomic Changes During the Replicative Senescence of Human Articular Chondrocytes

12 Nov 2024

Abstract excerpt

Aging is a major risk factor for osteoarthritis (OA), but the specific mechanisms connecting aging and OA remain unclear. Although chondrocytes rarely divide in adult articular cartilage, they undergo replicative senescence in vitro, offering a model to study aging-related changes under controlled conditions. OA cartilage was obtained from an 80-year-old male and a 72-year-old female, while normal cartilage was...

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PMID: 39596199
DOI: 10.3390/ijms252212130

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