Article

Targeting endogenous K-RAS for degradation through the affinity-directed protein missile system

2019-10-16

Abstract excerpt

For over three decades, K-RAS has been known as the holy grail of cancer targets, one of the most frequently mutated oncogenes in cancer. Because the development of conventional small molecule K-RAS inhibitors has been extremely challenging, K-RAS has been dubbed as an undruggable target, and only recently a mutation specific inhibitor has reached clinical trials. Targeted protein degradation has emerged as a new...

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Literature Corpus work: 99ee1fa4-8b0a-537f-b544-0bd3964147d2
DOI: 10.1101/805150

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