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Inhibition of NFAT promotes loss of tissue resident uterine natural killer cells and attendant pregnancy complications in humans

2024-03-12

Abstract excerpt

Uterine natural killer cells (uNKs) are a tissue resident lymphocyte population that are critical for pregnancy success. Although mouse models have demonstrated that NK deficiency results in abnormal placentation and poor pregnancy outcomes, the generalizability of this knowledge to humans remains unclear. Here we identify uterus transplant (UTx) recipients as a human population with reduced uNK cells and altered...

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Identifiers and source

Literature Corpus work
99a0ffbf-d6ee-5422-a8de-5815f68abf71
DOI
10.1101/2024.03.07.583906
Open publication

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Inhibition of NFAT promotes loss of tissue resident uterine natural killer cells and attendant pregnancy complications in humansDOI 10.1101/2024.03.07.583906
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