Article

Specific HLA Class I and II alleles are associated with a higher risk for tumor formation in Neurofibromatosis type 1

2026-05-05

Abstract excerpt

Neurofibromatosis type 1 (NF1) is a common autosomal dominant genetic tumor predisposition syndrome. 1 NF1 patients display remarkable phenotypic variability, even within families carrying the same NF1 mutation. 2 With few exceptions, the identification of specific genotype-phenotype correlations has remained elusive. 3–6 We utilized RNA-seq data and direct DNA sequencing to determine HLA genotypes for individ...

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Literature Corpus work: 99188e0f-ff39-519b-92ea-2596a46ae605
DOI: 10.64898/2026.05.04.26352173

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