Back to search

Article

A comparative ‘omics approach to candidate pathogenicity factor discovery in the brain-eating amoeba <i>Naegleria fowleri</i>

2020-01-16

Abstract excerpt

Of the 40 described Naegleria species, only N. fowleri can establish infection in humans, killing almost invariably within two weeks. In the brain, the amoeba performs piece-meal ingestion, or trogocytosis, of brain material causing massive inflammation. Conversely, its close relative Naegleria gruberi , which is used as a laboratory model organism, is non-pathogenic. The exact pathogenicity factors distinguish...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
990229e6-a042-59f5-a54c-40e459b1d547
DOI
10.1101/2020.01.16.908186
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A comparative ‘omics approach to candidate pathogenicity factor discovery in the brain-eating amoeba <i>Naegleria fowleri</i>DOI 10.1101/2020.01.16.908186
Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleriSemantic proximity
Nanopore sequencing improves the draft genome of the human pathogenic amoeba Naegleria fowleriSemantic proximity
The genome of Naegleria lovaniensis, the basis for a comparative approach to unravel pathogenicity factors of the human pathogenic amoeba N. fowleriSemantic proximity
Genome-wide identification of pathogenicity factors of the free-living amoeba Naegleria fowleriSemantic proximity
Adaptive iron utilization compensates for the lack of an inducible uptake system in <i>Naegleria fowleri</i> and represents a potential target for therapeutic interventionSemantic proximity
<i>Naegleria fowleri:</i> protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoebaSemantic proximity
The Mitochondrial Genome and a 60‐kb Nuclear DNA Segment from Naegleria fowleri, the Causative Agent of Primary Amoebic MeningoencephalitisSemantic proximity
Molecular, cellular and neurological consequences of infection by the neglected human pathogen NocardiaSemantic proximity
Comparative genomic analysis of the Hafnia genus reveals an explicit evolutionary relationship between the species alvei and paralvei and provides insights into pathogenicitySemantic proximity
Comprehensive Comparative Genomics Reveals Over 50 Phyla of Free-living and Pathogenic Bacteria are Associated with Diverse Members of the AmoebozoaSemantic proximity
New and revised gene ontology biological process terms describe multiorganism interactions critical for understanding microbial pathogenesis and sequences of concernSemantic proximity
The zoonotic pathogen Wohlfahrtiimonas chitiniclastica – current findings from a clinical and genomic perspectiveSemantic proximity
Select a neighboring publication to make it the new centre.