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Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri

22 Jul 2021

Abstract excerpt

BACKGROUND: The opportunistic pathogen Naegleria fowleri establishes infection in the human brain, killing almost invariably within 2 weeks. The amoeba performs piece-meal ingestion, or trogocytosis, of brain material causing direct tissue damage and massive inflammation. The cellular basis distinguishing N. fowleri from other Naegleria species, which are all non-pathogenic, is not known. Yet, with the geographic...

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PMID: 34294116
DOI: 10.1186/s12915-021-01078-1

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