Article

miRNA binding pressure channels evolution of SARS-CoV-2 genomes

2023-03-31

Abstract excerpt

In somatic cells, microRNAs (miRNAs) bind to the genomes of RNA viruses and influence their translation and replication. Here we demonstrate that a significant number of miRNA binding sites locate in the NSP4 region of the SARS-CoV-2 genome, and the intestinal human miRNAs exert evolutionary pressure on this region. Notably, in infected cells, NSP4 promotes the formation of double-membrane vesicles, which serve as...

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Literature Corpus work: 98fba9f8-2020-5900-9c27-532bf7500e88
DOI: 10.1101/2023.03.31.535057

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