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Article

The impact of host microRNAs on the development of conserved mutations of SARS-CoV-2.

Scientific reports - 27 Sept 2024

Ghaemi Shokoofeh, Abdoli Asghar, Karimi Hesam, Saadatpour Fatemeh, Arefian Ehsan

Abstract excerpt

SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has undergone various genetic alterations due to evolutionary pressures exerted by host cells, including intracellular antiviral mechanisms such as targeting by human microRNAs (miRNAs). This study investigates the impact of miRNAs hsa-miR-3132 and hsa-miR-4650 on the viral genome. Sequence alignment revealed conserved mutations in the binding sites of...

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Identifiers

PMID: 39333651
DOI: 10.1038/s41598-024-70974-7
PMCID: PMC11437047

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