Article

The signature of SARS-CoV-2 evolution reflects selective pressures within human guts

2023-04-07

Abstract excerpt

In somatic cells, microRNAs (miRNAs) bind to the genomes of RNA viruses and influence their translation and replication. Here we demonstrate that a significant number of miRNA binding sites locate in the NSP4 region of the SARS-CoV-2 genome, and the intestinal human miRNAs exert evolutionary pressure on this region. Notably, in infected cells, NSP4 promotes the formation of double-membrane vesicles, which serve as...

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Literature Corpus work: 05c2881c-9812-5bcc-98c2-e142d6e5407c
DOI: 10.22541/au.168087440.01190871/v1

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