Article

Cyclin E1 protein is stabilized in <i>BRCA1</i> mutated breast cancers leading to synergy between CDK2 and PARP inhibitors

2020-01-30

Abstract excerpt

<h4>ABSTRACT</h4> Basal-like breast cancers (BLBC) are aggressive breast cancers that respond poorly to targeted therapies and chemotherapies. In order to define therapeutically targetable subsets of BLBC we examined two markers: cyclin E1 and BRCA1 loss. In high grade serous ovarian cancer (HGSOC) these markers are mutually exclusive, and define therapeutic subsets. We tested the same hypothesis for BLBC. Usin...

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Literature Corpus work: 98f468cb-293d-5bbb-8187-3bb04077be26
DOI: 10.1101/2020.01.29.911883

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