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Article

Single-section spatial hypoxia–cytotoxic associations do not consistently reproduce across breast cancer patients

2026-06-17

Abstract excerpt

Spatial transcriptomics can reveal localized tumor–immune relationships, but thousands of spots from one tissue section do not provide thousands of biological replicates. We evaluated the distinction between within-section association and patient-level reproducibility using public breast cancer datasets. In a 10x Genomics Visium discovery section containing 3,798 spots, hypoxia-related transcription was inversely...

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Literature Corpus work
98c74a27-3508-5292-aa0f-b551472e185d
DOI
10.64898/2026.06.13.732045
Open publication

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Single-section spatial hypoxia–cytotoxic associations do not consistently reproduce across breast cancer patientsDOI 10.64898/2026.06.13.732045
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