Article

Isomerization of antimalarial drug WR99210 explains its inactivity in a commercial stock

2020-07-01

Abstract excerpt

<h4>ABSTRACT</h4> WR99210, a former antimalarial drug candidate now widely used for the selection of Plasmodium transfectants, selectively targets the parasite dihydrofolate reductase thymidine synthase bifunctional enzyme (DHFR-TS) but not human DHFR, which is not fused with TS. Accordingly, WR99210 and plasmids expressing human dhfr have become valued tools for the genetic modification of parasites in the lab...

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Literature Corpus work: 9860aebe-8f72-5578-8c01-5dc91d9e96e9
DOI: 10.1101/2020.07.01.182402

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