Article

Structure-Activity Relationships in the Design of Mitochondria-Targeted Peptide Therapeutics

2021-11-09

Abstract excerpt

Mitochondria play a central role in metabolic homeostasis; hence, dysfunction of this organelle underpins the etiology of many heritable and aging-related diseases. Mitochondria-targeted tetrapeptides with alternating cationic and aromatic residues, such as SS-31 (Elamipretide), show promise as therapeutic compounds. In this study, we conducted a quantitative structure-activity analysis of three alternative tetrap...

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Literature Corpus work: 98357b9a-479a-56b0-9656-aec5c386d0d3
DOI: 10.1101/2021.11.08.467832

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