CircARHGAP12 suppresses cisplatin-induced alkaliptosis in nasopharyngeal carcinoma through G3BP1-mediated upregulation of CA9 in an RNA G-quadruplex-dependent manner

Abstract excerpt

<title>Abstract</title> <p>Background Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor with a high prevalence in Southern China, and cisplatin remains a commonly used first-line chemotherapeutic agent. However, the effectiveness of cisplatin-based therapy is often compromised by the development of drug resistance, posing a major clinical challenge. Our previous studies demonstrated that circular RNA...

Topics

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• Cell Transformation, Neoplastic
• Drug Resistance, Neoplasm
• Enzyme function and inhibition
• GTP-Binding Protein alpha Subunits
• GTP-Binding Protein alpha Subunits, G12-G13
• Mice, Inbred NOD
• Mice, SCID
• Renal cell carcinoma treatment

Identifiers and source

Literature Corpus work

9824c323-b836-5e38-bf29-d95bd2c07414

DOI

10.21203/rs.3.rs-7984659/v1