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Increased power from bacterial genome-wide association conditional on known effects identifies <i>Neisseria gonorrhoeae</i> macrolide resistance mutations in the 50S ribosomal protein L4

2020-03-25

Abstract excerpt

The emergence of resistance to azithromycin complicates treatment of N. gonorrhoeae , the etiologic agent of gonorrhea. Population genomic analyses of clinical isolates have demonstrated that some azithromycin resistance remains unexplained after accounting for the contributions of known resistance mutations in the 23S rRNA and the MtrCDE efflux pump. Bacterial genome-wide association studies (GWAS) offer a promi...

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Literature Corpus work
98238fb6-b3ef-5764-bd16-4d5edb23d0e5
DOI
10.1101/2020.03.24.006650
Open publication

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Increased power from bacterial genome-wide association conditional on known effects identifies <i>Neisseria gonorrhoeae</i> macrolide resistance mutations in the 50S ribosomal protein L4DOI 10.1101/2020.03.24.006650
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