Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae.

Nature communications - 23 Oct 2020

Ma Kevin C, Mortimer Tatum D, Duckett Marissa A, Hicks Allison L, Wheeler Nicole E, Sánchez-Busó Leonor, Grad Yonatan H

Abstract excerpt

The emergence of resistance to azithromycin complicates treatment of Neisseria gonorrhoeae, the etiologic agent of gonorrhea. Substantial azithromycin resistance remains unexplained after accounting for known resistance mutations. Bacterial genome-wide association studies (GWAS) can identify novel resistance genes but must control for genetic confounders while maintaining power. Here, we show that compared to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azithromycin
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Bacterial

Share to Gonorrhea

Share to Macrolides

Share to Microbial Sensitivity Tests

Share to Neisseria gonorrhoeae

Share to RNA, Ribosomal, 23S

Source

Open in PubMed Open full text

Identifiers

PMID: 33097713
DOI: 10.1038/s41467-020-19250-6
PMCID: PMC7584619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae.PMID 33097713Read ↗

Increased power from bacterial genome-wide association conditional on known effects identifies <i>Neisseria gonorrhoeae</i> macrolide resistance mutations in the 50S ribosomal protein L4Semantic proximity Read ↗

The Synergistic Armory: A Global Genome-Wide Association Study Reveals the Integrated Mechanisms of Azithromycin Resistance in Neisseria gonorrhoeae.Semantic proximity Read ↗

Loci for prediction of penicillin and tetracycline susceptibility in <i>Neisseria gonorrhoeae</i> : a genome wide association studySemantic proximity Read ↗

Loci for prediction of penicillin and tetracycline susceptibility in Neisseria gonorrhoeae: a genome-wide association studySemantic proximity Read ↗

Holistic understanding of trimethoprim resistance in Streptococcus pneumoniae using an integrative approach of genome-wide association study, resistance reconstruction, and machine learning.Semantic proximity Read ↗

Reliability of Genetic Alterations in Predicting Ceftriaxone Resistance in Neisseria gonorrhoeae Globally.Semantic proximity Read ↗

Genome-wide association, prediction and heritability in bacteriaSemantic proximity Read ↗

Machine learning to predict ceftriaxone resistance using single nucleotide polymorphisms within a global database of Neisseria gonorrhoeae genomes.Semantic proximity Read ↗

Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae.Semantic proximity Read ↗

Microbial genome-wide association studies: lessons from human GWAS.Semantic proximity Read ↗

Targeted surveillance strategies for efficient detection of novel antibiotic resistance variantsSemantic proximity Read ↗

Genome-Wide Transposon Mutagenesis Screens Identify Group A Streptococcus Genes Affecting Susceptibility to β-Lactam AntibioticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.