Article

Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics

2022-10-19

Abstract excerpt

Vascular Ehlers-Danlos Syndrome (vEDS) is a rare autosomal dominant disease caused by mutations in the COL3A1 gene, which renders patients susceptible to aneurysm and arterial dissection and rupture. To determine the role of COL3A1 variants in the biochemical and biophysical properties of human arterial ECM, we developed a method for synthesizing ECM directly from vEDS donor fibroblasts. We found that the protei...

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Literature Corpus work: 9804c7ca-7f5f-5bfe-91d9-b79efa373531
DOI: 10.1101/2022.10.16.512399

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