Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics.

Acta biomaterialia - 1 Aug 2023

Doherty Elizabeth L, Aw Wen Yih, Warren Emily C, Hockenberry Max, Whitworth Chloe P, Krohn Grace, Howell Stefanie, Diekman Brian O, Legant Wesley R, Nia Hadi Tavakoli, Hickey Anthony J, Polacheck William J

Abstract excerpt

Vascular Ehlers-Danlos Syndrome (vEDS) is a rare autosomal dominant disease caused by mutations in the COL3A1 gene, which renders patients susceptible to aneurysm and arterial dissection and rupture. To determine the role of COL3A1 variants in the biochemical and biophysical properties of human arterial ECM, we developed a method for synthesizing ECM directly from vEDS donor fibroblasts. We found that the protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Collagen Type III
Share to Ehlers-Danlos Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Extracellular Matrix

Share to Mutation

Share to Mutation, Missense

Source

Open in PubMed Open full text

Identifiers

PMID: 37187299
DOI: 10.1016/j.actbio.2023.05.015
PMCID: PMC10330735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics.PMID 37187299Read ↗

Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanicsSemantic proximity Read ↗

Integrative Multi-Omics Approach in Vascular Ehlers-Danlos Syndrome: Further Insights into the Disease Mechanisms by Proteomic Analysis of Patient Dermal FibroblastsSemantic proximity Read ↗

Aortic Tissue Proteome Alterations in Vascular Ehlers-Danlos Syndrome.Semantic proximity Read ↗

Dysregulation of extracellular matrix and Lysyl Oxidase in Ehlers-Danlos Syndrome Type IV skin fibroblastsSemantic proximity Read ↗

Transcriptome analysis of skin fibroblasts with dominant negative COL3A1 mutations provides molecular insights into the etiopathology of vascular Ehlers-Danlos syndrome.Semantic proximity Read ↗

Molecular diagnosis in vascular Ehlers-Danlos syndrome predicts pattern of arterial involvement and outcomes.Semantic proximity Read ↗

What Every Vascular Surgeon Should Know About Vascular Ehlers-Danlos Syndrome.Semantic proximity Read ↗

Generation of two iPSC lines from vascular Ehlers-Danlos Syndrome (vEDS) patients carrying a missense mutation in COL3A1 geneSemantic proximity Read ↗

Novel compound heterozygous COL3A1 variants are associated with Vascular Ehlers-Danlos SyndromeSemantic proximity Read ↗

Type III collagen affects dermal and vascular collagen fibrillogenesis and tissue integrity in a mutant Col3a1 transgenic mouse model.Semantic proximity Read ↗

Vascular Ehlers-Danlos syndrome: pathophysiology, diagnosis, and prevention and treatment of its complications.Semantic proximity Read ↗

Vascular Ehlers-Danlos Syndrome: A Comprehensive Natural History Study in a Dutch National Cohort of 142 Patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.