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Article

Impacts of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of apixaban in patients with non-valvular atrial fibrillation.

2022-05-23

Abstract excerpt

<h4>Purpose: </h4> We examined the impact of polymorphisms in genes encoding cytochrome P450 (CYP) 3A5 (gene code CYP3A5 ), P-glycoprotein ( ABCB1 ), breast cancer resistance protein ( ABCG2 ), cytochrome P450 oxidoreductase ( POR ) and pregnane X receptor (PXR; NR1I2 ) on the steady-state trough concentrations (C 0h ) of apixaban. <h4>Methods: </h4>: The analyses included 86 patients with non-valvular atrial fibr...

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Literature Corpus work
97f8a653-8e65-56d4-b3b2-4dd0c7f5a2b9
DOI
10.21203/rs.3.rs-1661172/v1
Open publication

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Impacts of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of apixaban in patients with non-valvular atrial fibrillation.DOI 10.21203/rs.3.rs-1661172/v1
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