Article
The Influence of ABCB1 (rs1045642 and rs4148738) Gene Polymorphisms on Rivaroxaban Pharmacokinetics in Patients Aged 80 Years and Older with Nonvalvular Atrial Fibrillation.
High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension - 1 Sept 2022
Sychev Dmitry, Ostroumova Olga, Cherniaeva Marina, Shakhgildian Nataliia, Mirzaev Karin, Abdullaev Sherzod, Denisenko Natalia, Sozaeva Zhannet, Kachanova Anastasia, Gorbatenkova Svetlana, Shastina Vera
Abstract excerpt
INTRODUCTION: ABCB1 gene polymorphisms are associated with rivaroxaban distribution changes and adverse reactions but the data are controversial. AIM: To evaluate the influence of ABCB1 (rs1045642 and rs4148738) gene polymorphisms on rivaroxaban pharmacokinetics in patients aged 80 years and older with nonvalvular atrial fibrillation (NAF). METHODS: 128 patients aged 80 years and older (median [Me] age 87.5...
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