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Article

Chronic inflammation of middle ear cholesteatoma promotes its recurrence via a paracrine mechanism

2020-09-18

Abstract excerpt

<h4>Background: </h4> Cholesteatoma disease is an expanding lesion in the middle ear. Hearing loss and facial paralysis alongside with other intracranial complications are found. No pharmaceutical treatment is available today and recurrence after surgical extraction occurs. We investigated possible TLR4-based mechanisms promoting recurrence and explore possible treatments strategies.MethodsWe isolated fibroblasts...

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Identifiers and source

Literature Corpus work
044f7581-05b3-5a99-b894-cd3f6995f56b
DOI
10.21203/rs.3.rs-74086/v1
Open publication

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