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Article

Identification of Novel Cholesteatoma-Related Gene Expression Signatures Using Full-Genome Microarrays

20 Dec 2012

Abstract excerpt

BACKGROUND: Cholesteatoma is a gradually expanding destructive epithelial lesion within the middle ear. It can cause extensive local tissue destruction in the temporal bone and can initially lead to the development of conductive hearing loss via ossicular erosion. As the disease progresses, sensorineural hearing loss, vertigo or facial palsy may occur. Cholesteatoma may promote the spread of infection through the...

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PMID: 23285167
DOI: 10.1371/journal.pone.0052718

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