Article
Proto-oncogene mutations in middle ear cholesteatoma contribute to its pathogenesis.
BMC medical genomics - 15 Nov 2023
Satoh Chisei, Yoshiura Koh-Ichiro, Mishima Hiroyuki, Yoshida Haruo, Takahashi Haruo, Kumai Yoshihiko
Abstract excerpt
BACKGROUND: Chronic inflammation causes bone destruction in middle ear cholesteatomas (MECs). However, the causes of their neoplastic features remain unknown. The present study demonstrated for the first time that neoplastic features of MEC are based on proto-oncogene mutations. RESULTS: DNA was extracted from MEC and blood samples of five patients to detect somatic mutations using depth-depth exome sequencing....
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