Sex dimorphism of IL-17-secreting peripheral blood mononuclear cells in ankylosing spondylitis based on bioinformatics analysis and machine learning

Abstract excerpt

<h4>Background: </h4> Ankylosing spondylitis (AS) with radiographic damage is more prevalent in men than in women. IL-17, which is mainly secreted from peripheral blood mononuclear cells (PBMCs), plays an important role in the development of AS. Its expression is different between male and female. However, it is still unclear whether sex dimorphism of IL-17 contribute to sex differences in AS. Methods GSE221786,...

Topics

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• Causality
• Genome-Wide Association Study
• HLA-DR Antigens
• Lipopolysaccharide Receptors
• Mendelian Randomization Analysis
• Monocytes
• Spondylitis, Ankylosing
• Spondyloarthritis Studies and Treatments

Identifiers and source

Literature Corpus work

10deb635-46f5-570b-8df6-9fba872406a1

DOI

10.21203/rs.3.rs-4129727/v1