T-cell specific upregulation of Sema4A as risk factor for autoimmunity in systemic lupus erythematosus and rheumatoid arthritis.

doi:10.1080/08916934.2019.1704273

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Article

T-cell specific upregulation of Sema4A as risk factor for autoimmunity in systemic lupus erythematosus and rheumatoid arthritis.

Autoimmunity - 1 Mar 2020

Cavalcanti Catarina Addobbati Jordão, Germoglio Vanessa, de Azevêdo Silva Jaqueline, Glesse Nadine, Vianna Priscila, Cechim Giovana, Monticielo Odirlei Andre, Xavier Ricardo Machado, Brenol João Carlos Tavares, Brenol Claiton Viegas, Fragoso Thiago Sotero, Barbosa Alexandre Domingues, Duarte Ângela Luiza Branco Pinto, Oliveira Renê Donizeti Ribeiro, Louzada-Júnior Paulo, Donadi Eduardo Antônio, Chies José Artur Bogo, Crovella Sergio, Sandrin-Garcia Paula

Abstract excerpt

The aim of the present study was to evaluate the impact of SEMA4A genetic variants on expression of sema4A protein and its relation to autoimmunity development in Systemic Lupus Erythematosus and Rheumatoid Arthritis patients. A total of 541 SLE patients, 390 RA patients and 607 healthy individuals were genotyped. We also assessed SEMA4A mRNA expression from whole blood cells and the in vitro protein production...

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PMID: 31876207
DOI: 10.1080/08916934.2019.1704273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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