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ONECUT2 governs the POU6F2-beta-catenin axis to modulate cancer stemness and drives the CCL28-dependent pathway for macrophage polarization in breast cancer

2025-10-15

Abstract excerpt

<title>Abstract</title> <p>Cancer stem cells (CSC) and the immunosuppressive microenvironments are key drivers of breast cancer (BC) progression and drug resistance. However, the molecular mechanisms by which One Cut Homeobox 2 (ONECUT2) governs CSC and the tumor immune microenvironment (TIME) remains largely unknown. Given the critical knowledge gap, we sought to investigate ONECUT2’s regulatory impact on CSC pr...

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Literature Corpus work
9685f83b-5c56-58c6-9af0-9a3588d0abb3
DOI
10.21203/rs.3.rs-7518380/v1
Open publication

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ONECUT2 governs the POU6F2-beta-catenin axis to modulate cancer stemness and drives the CCL28-dependent pathway for macrophage polarization in breast cancerDOI 10.21203/rs.3.rs-7518380/v1
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