Article

Bighorn sheep T2T genome assembly reveals differences in immune genes: a potential cause of high morbidity due to respiratory pathogens

2025-10-02

Abstract excerpt

The bighorn sheep ( Ovis canadensis ), despite its close relation to domestic sheep, suffer higher morbidity and mortality from respiratory disease complexes, likely due to genetic differences in immune responses. Unraveling highly repetitive regions such as immune loci and genetic differences was problematic until now. We generated a bighorn sheep telomere-to-telomere assembly, adding 14.28% of novel sequence co...

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Literature Corpus work: 9644fd57-b0ec-5848-bf79-fe2f3c1f81e5
DOI: 10.1101/2025.09.30.679298

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