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Telomere-to-telomere sheep genome assembly identifies variants associated with wool fineness.

Nature genetics - 1 Jan 2025

Luo Ling-Yun, Wu Hui, Zhao Li-Ming, Zhang Ya-Hui, Huang Jia-Hui, Liu Qiu-Yue, Wang Hai-Tao, Mo Dong-Xin, EEr He-Hua, Zhang Lian-Quan, Chen Hai-Liang, Jia Shan-Gang, Wang Wei-Min, Li Meng-Hua

Abstract excerpt

Ongoing efforts to improve sheep reference genome assemblies still leave many gaps and incomplete regions, resulting in a few common failures and errors in genomic studies. Here, we report a 2.85-Gb gap-free telomere-to-telomere genome of a ram (T2T-sheep1.0), including all autosomes and the X and Y chromosomes. This genome adds 220.05 Mb of previously unresolved regions and 754 new genes to the most updated...

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PMID: 39779954
DOI: 10.1038/s41588-024-02037-6

Genes

ABCC4
FOXQ1

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