Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The SMN-ribosome interplay: a new opportunity for Spinal Muscular Atrophy therapies.

Biochemical Society transactions - 28 Feb 2024

Sharma Gaurav, Paganin Martina, Lauria Fabio, Perenthaler Elena, Viero Gabriella

Abstract excerpt

The underlying cause of Spinal Muscular Atrophy (SMA) is in the reduction of survival motor neuron (SMN) protein levels due to mutations in the SMN1 gene. The specific effects of SMN protein loss and the resulting pathological alterations are not fully understood. Given the crucial roles of the SMN protein in snRNP biogenesis and its interactions with ribosomes and translation-related proteins and mRNAs, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA modifications and cancer
Share to Muscular Atrophy, Spinal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neurogenetic and Muscular Disorders Research

Share to Ribosomes

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 38391004
DOI: 10.1042/BST20231116
PMCID: PMC10903476

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The SMN-ribosome interplay: a new opportunity for Spinal Muscular Atrophy therapies.PMID 38391004Read ↗

In Vivo Translatome Profiling in Spinal Muscular Atrophy Reveals a Role for SMN Protein in Ribosome BiologySemantic proximity Read ↗

<i>In vivo</i> translatome profiling reveals early defects in ribosome biology underlying SMA pathogenesisSemantic proximity Read ↗

The SMN Complex at the Crossroad between RNA Metabolism and NeurodegenerationSemantic proximity Read ↗

Spliceosomal small nuclear ribonucleoprotein biogenesis defects and motor neuron selectivity in spinal muscular atrophy.Semantic proximity Read ↗

Mitochondrial Dysfunction in Spinal Muscular AtrophySemantic proximity Read ↗

SMN in spinal muscular atrophy and snRNP biogenesisSemantic proximity Read ↗

Spinal Muscular Atrophy: From Defective Chaperoning of snRNP Assembly to Neuromuscular DysfunctionSemantic proximity Read ↗

Genome-wide identification of mRNAs associated with the protein SMN whose depletion decreases their axonal localizationSemantic proximity Read ↗

SMN protein promotes membrane compartmentalization of ribosomal protein S6 transcript in human fibroblastsSemantic proximity Read ↗

Translation-specific disruption of Col1a1 expression in multiple models of Spinal Muscular Atrophy can be rescued by Risdiplam.Semantic proximity Read ↗

Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor NeuronsSemantic proximity Read ↗

The Role of RNA Binding Proteins for Local mRNA Translation: Implications in Neurological DisordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.